Engineering of a functional γ-tocopherol transfer protein
نویسندگان
چکیده
منابع مشابه
Alpha-Tocopherol Transfer Protein (α-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice
Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. Genetic defects in alpha-TTP, like dietary vitamin E deficiency, are associated with infertility, muscular weakness and neurological disorders. Both human and alpha-TTP deficient (alpha-TTP(-/-)) mice exhibit severe pla...
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gamma-Tocopherol, the major form of dietary vitamin E, is absorbed in the intestine and is secreted in chylomicrons, which are then transferred to liver lysosomes. Most gamma-tocopherol is transferred to liver microsomes and is catabolized by cytochrome p450. Due to the hydrophobicity of gamma-tocopherol, a binding and transfer protein is plausible, but none have yet been isolated and character...
متن کاملUrinary a -tocopherol metabolites in a -tocopherol transfer protein-deficient patients
Patients with a -tocopherol transfer protein ( a TTP) defects experience neurological symptoms characteristic of vitamin E deficiency and depend on continuous high a -tocopherol supplements. We investigated the excretion of 2,5,7,8-tetramethyl-2(2 9 -carboxyethyl)-6-hydroxychroman ( a -CEHC), a urinary metabolite of a -tocopherol, as a putative marker for the a -tocopherol status of a -TTP-defi...
متن کاملThe α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis
The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring TTP's significance during fetal development. TTP an...
متن کاملTocopherol transfer protein sensitizes prostate cancer cells to vitamin E.
Prostate cancer is a major cause of mortality in men in developed countries. It has been reported that the naturally occurring antioxidant α-tocopherol (vitamin E) attenuates prostate cancer cell proliferation in cultured cells and mouse models. We hypothesized that overexpression of the tocopherol transfer protein (TTP), a vitamin E-binding protein that regulates tocopherol status, will sensit...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2021
ISSN: 2213-2317
DOI: 10.1016/j.redox.2020.101773